IS-II Implant Placement with Guided Bone Regeneration Using CTi-mem: A 13-Year Follow-Up Case

Case Summary 🔎

Patient Information

•Age/Gender: 52-year-old, Female

•Past Medical History: Healthy

•Drug allergy: None

•Chief complaint: "I have the missing teeth on the upper front area."

Introduction

This case presents a 52-year-old male patient who underwent implant placement in the maxillary anterior region (#23) with simultaneous guided bone regeneration (GBR) using CTi-mem, a titanium mesh. An IS-II implant was placed, and the CTi-mem was used to stabilize the grafted bone and maintain the desired contour. The titanium mesh was removed three months after surgery, followed by prosthetic rehabilitation. Clinical and radiographic follow-up was performed over a period of 13 years, demonstrating stable peri-implant bone conditions and favorable long-term outcomes.

Treatment Plan

1. Placement of CMI IS-II implant at site #23

2. Simultaneous guided bone regeneration (GBR) using CTi-mem (titanium mesh)

3. Removal of the CTi-mem 3 months after surgery

4. Delivery of the definitive restoration 

5. Annual clinical and radiographic follow-up

Case Presentation

1️⃣ Pre-Op

• Pre-operative radiograph and intraoral photograph shows well-healed alveolar ridge.

  
  

  

2️⃣ Surgery

• Flap elevation was performed, revealing insufficient buccal bone.

  

• A CMI IS-II implant (Ø4.0 × 10 mm) was placed at site #23. Due to insufficient buccal bone, the buccal aspect of the implant was exposed.

  

  

• Bone grafting was performed using allogenic bone.

  

• The CTi-mem (B1) was contoured and secured to the implant at the surgical site.

  

  

  

• Primary closure was achieved with suturing to prevent exposure of the CTi-mem.

  

  

• Post operative panoramic radiograph (May 23, 2011)

  

• Sutures were removed two weeks postoperatively, and the soft tissue showed uneventful healing.

  

  

• The CTi-mem was removed 3 months after surgery.

  

  

  

• The healing abutment was connected.

  

  

3️⃣ Final Restoration

• The definitive prosthetic restoration was fabricated.

  

  

• Definitive prostheses were delivered  1 year after surgery. (June 29, 2012)

  

  

  

4️⃣ Periodic follow-up (April 2013 – March 2025)

• Annual panoramic radiographs were taken consecutively from April 2013 to March 2025.

  

  

  

  

  

  

  

  

  

  

  

  

  

From May 2011 to March 2025, annual follow-up evaluations showed stable long-term maintenance with no evidence of bone loss.

Summary

This case demonstrates favorable long-term outcomes of guided bone regeneration using CTi-mem in conjunction with IS-II implant placement. The regenerated bone area maintained stable volume and contour for more than 13 years without evidence of resorption. In addition, the IS-II implant showed excellent long-term stability with no marginal bone loss throughout the follow-up period. These findings suggest that CTi-mem–based GBR can provide predictable and durable results, supporting long-term implant success.